The Truth About Truth Serum

Popular culture makes gratuitous use of powerful lie-repelling agents known as Truth Serums. They are usually depicted as injected drugs which strongly inhibit a subject’s ability to lie, causing him or her to mechanically recite the truth to an interviewer upon questioning.
Such drugs have been utilized by some of the three-letter government agencies in the not-so-distant past (CIA, FBI, DOD, KGB, etc.), particularly during the rampant paranoia of the Cold War. And in the aftermath of 9/11, there was some discussion on the idea of bringing them back into use for interrogation. But are these truth serums effective? Do they produce any useful results?
The short answer is, no. The long answer is “Noooooooooooo!”, preferably while running in slow-motion.
Many barbiturates fall under the “truth serum” category, including scopolamine, sodium amytal, and Sodium Pentothal. Scopolamine was tested in the 1950s as a truth serum in project MKULTRA, and is now infamous as a date-rape drug due to its tendency to cause retrograde amnesia (the inability to recall events prior to its administration). Sodium Pentothal is a drug which is commonly used in operating rooms as general anesthesia, though in recent years it has been largely replaced by better alternatives.
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